Journal: Scientific Reports
Article Title: Rosemary essential oil: chemical composition, antiviral, cytotoxicity, and in silico molecular docking analysis against tobacco mosaic virus
doi: 10.1038/s41598-025-24071-y
Figure Lengend Snippet: Proposed antiviral actions of rosemary essential oil against tobacco mosaic virus (TMV). This figure illustrates the proposed pathways by which rosemary essential oil inhibits TMV infection, derived from protective, curative, and inactivation assays, as well as in silico molecular docking analysis. The protective pathway indicates that viral entry can be inhibited via a physical barrier or through modulation of host cells. The curative pathway, exhibiting the greatest efficacy, entails the inhibition of two critical intracellular processes: viral replication and viral movement. The inactivation pathway indicates a direct virucidal effect, wherein compounds compromise the integrity of the TMV coat protein. These mechanisms collectively result in a notable decrease in viral load and disease symptoms in Nicotiana glutinosa .
Article Snippet: The collected samples at 5 dpi were transferred to the lab and directly evaluated for TMV infection using DAS-ELISA (DSMZ No.: RT-1065), according to the manufacturer’s instructions .
Techniques: Virus, Infection, Derivative Assay, In Silico, Inhibition